Gubei Smile Dental International Medical Center announces a strategic partnership with Heyuanhemei (Shanghai) Biotechnology Co., Ltd. , a wholly-owned subsidiary of OBiO Technology (688238.SH), to officially launch a Dental Pulp Stem Cell Banking Program. The collaboration integrates clinical extraction capabilities with advanced cell processing and cryopreservation technologies, creating a closed-loop service model spanning "diagnosis, extraction, and storage" – transforming teeth that would otherwise be discarded as medical waste into long-term biological reserves.
Partnership Profile:
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Gubei Smile Dental International Medical Center: With over a decade of presence in Shanghai's Gubei international community, the center brings together dental specialists from China, Japan, South Korea, and Australia. Its experienced clinical team and international service framework provide the front-end technical foundation for standardized dental pulp stem cell collection.
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Heyuanhemei: A wholly-owned subsidiary of OBiO Technology (688238.SH), Heyuanhemei specializes in regenerative medicine and anti-aging therapeutics, offering CRO/CDMO services including cell preparation, exosome and cytokine production, and cell banking. The company's production facility is located in the Lin-gang Special Area of Shanghai Pilot Free Trade Zone, ensuring cell safety and scalable production from the source.
Applicable Scenarios and Collection Workflow:
Dental pulp stem cells are mesenchymal stem cells isolated from the dental pulp tissue, possessing self-renewal and multi-lineage differentiation capabilities. They are recognized by the international academic community as important seed cells for oral tissue regeneration and repair. This program covers three common extraction scenarios:
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Deciduous tooth exfoliation in children: Naturally exfoliated or Grade II mobile deciduous teeth (ages 5-12) with healthy, red pulp tissue and no caries – considered an optimal source of dental pulp stem cells;
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Orthodontic premolar extractions: Premolars extracted during adolescent orthodontic treatment, which offer ideal collection timing with good pulp health;
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Wisdom tooth extractions in adults: Fully erupted, caries-free wisdom teeth can also serve as a viable source of dental pulp stem cells.
The collection protocol includes: pre-extraction oral cleaning and disinfection; immediately placing the extracted intact tooth into a sterile collection vial containing preservation solution; and cold-chain transport at 2-8°C to the laboratory to maintain cell viability. At the facility, dental pulp mesenchymal stem cells are isolated via enzymatic digestion and cryopreserved in liquid nitrogen at temperatures below -150°C for long-term storage, awaiting future therapeutic applications.
Future Clinical Applications:
Dental pulp stem cells have demonstrated promising potential in multiple oral tissue regeneration research areas, including pulp-dentin complex regeneration, periodontal bone defect repair, periodontal ligament regeneration, and gingival soft tissue repair. As regenerative medicine continues to advance, cryopreserved dental pulp stem cells may play an increasingly important role in autologous tissue repair and anti-aging therapeutics.
Target Clientele and Strategic Significance:
This program primarily serves family clients in the Gubei area and beyond – especially families with children of appropriate age, adolescents undergoing orthodontic treatment, or adults scheduled for wisdom tooth extraction. The collection process requires no additional visits beyond routine extraction appointments, enabling families to simultaneously address immediate dental treatment needs while securing long-term health resources.
Gubei Smile Dental states that this partnership marks a strategic expansion from "single-service dental care" to "lifelong oral health management." The center will continue to explore deeper integration of regenerative medicine with clinical dentistry, delivering more forward-looking health protection options for its patients.
About Gubei Smile Dental
With an international dental team delivering multi-national standards of care, Gubei Smile Dental provides lifelong oral health management for Chinese and international families – from routine dental care and aesthetic restoration to regenerative medical reserves.
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